Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic morphine

The therapeutic benefits of opioids are compromised by the development of analgesic tolerance, which necessitates higher dosing for pain management thereby increasing the liability for drug dependence and addiction.Rodent models indicate opposing roles of the gut microbiota in tolerance: morphine-induced gut madelaine chocolate advent calendars dys

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GPS-based activity space exposure to greenness and walkability is associated with increased accelerometer-based physical activity

Introduction: Built and natural environments may provide opportunities for physical activity.However, studies are limited by primarily using residential addresses to define exposure and self-report to measure physical activity.We quantified associations between global positioning systems (GPS)-based activity space measures of environmental exposure

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Partnering with pediatric patients and families in high reliability to identify and reduce preventable safety events

Frameworks for dell 24 video conferencing monitor - s2422hz designing highly reliable behaviors and tools to reduce preventable harm are the result of the continued effort to improve patient safety in healthcare.Evidence shows that there has been limited research on engaging patients and families in the development of safety and reliability efforts

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